Step 1: Preheat oven to 375°F. Spray a medium skillet with cooking spray. Heat over medium-high heat. Add onions. Cook, stirring occasionally, until slightly soft, about 3-4 minutes.
Step 2: Mix onion, 1/4 cup ketchup, 1 tablespoon mustard, mozzarella, bread crumbs, parsley, Parmesan, oregano and egg in a large bowl. Add beef, garlic powder, salt and pepper. Mix lightly.
Step 3: Spray a loaf pan with cooking spray. Press beef mixture into pan. Combine remaining 1/2 ketchup and mustard in a small bowl. Spread over top of meat loaf.
Step 4: Bake meat loaf until set and cooked through, about 1 hour.
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