Step 1: Preheat oven to 400°F with rack in center.
Step 2: In small bowl, mix chili powder, garlic powder, cumin, cayenne and salt.
Step 3: On sheet pan, drizzle peppers and onion with 1 tablespoon oil. Toss with half of the spice mixture. Bake until lightly browned, 15 minutes.
Step 4: Meanwhile in medium bowl, toss fish, remaining 1 tablespoon oil and remaining spice mixture. Set aside.
Step 5: Push roasted vegetables to one half of pan; lay fish on other half. Return to oven; bake until fish is opaque and reaches a safe internal temperature of 145°F, 10 minutes. Squeezer lime over pan.
Step 6: Meanwhile prepare creamy taco sauce. Whisk mayonnaise, sour cream, lime juice and cayenne together in medium bowl. Season, to taste, with salt.
Step 7: Serve on warm tortillas with creamy taco sauce and avocado slices (if desired). Refrigerate any leftover.
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