Step 1: Preheat oven to 400F.
Step 2: Spray a large baking sheet with cooking spray or line with parchment paper; set aside.
Step 3: In a large bowl, combine flour, oat bran, cranberries, brown sugar, baking powder, baking soda and salt; set aside.
Step 4: In a medium bowl, whisk together the buttermilk, butter, orange zest and vanilla.
Step 5: Add wet ingredients to dry ingredients.
Step 6: Stir until a soft dough is formed.
Step 7: Add a bit more flour if dough is too sticky.
Step 8: Turn dough out onto a lightly floured surface.
Step 9: Divide into 2 pieces.
Step 10: Shape each piece into a ball.
Step 11: Place balls on baking sheet.
Step 12: Roll out or pat dough to 3/4" thick circles, about 6" in diameter.
Step 13: Using a sharp knife, cut each circle into 6 wedges, but do not separate them.
Step 14: To make glaze, lightly beat egg and 1 tablespoon water in a small bowl.
Step 15: Brush glaze lightly over top of dough (you will use less than half of it).
Step 16: Bake for 15-17 minutes, until scones are puffed up and golden.
Step 17: Cool slightly.
Step 18: Pull scones apart and serve warm.
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