Step 1: Position racks in centre and top third of oven.
Step 2: Preheat to 400F.
Step 3: Toss squash with oil on a baking sheet.
Step 4: Bake in centre of oven until tender, stirring halfway through, 16 - 18 minutes; remove to rack.
Step 5: Preheat broiler to 500F.
Step 6: Cook pasta in large pot of boiling unsalted water until al dente, about 7 - 8 minutes; drain.
Step 7: Melt butter in a medium saucepan over medium heat.
Step 8: Whisk in flour; mixture will be dry and very lumpy.
Step 9: Gradually whisk in milk, Dijon and cayenne (if using).
Step 10: Stir until mixture comes to a gentle boil, about 5 - 7 minutes.
Step 11: Remove pan from heat and stir in pasta, cheeses and squash until just coated.
Step 12: Do not melt cheese.
Step 13: Transfer to a casserole dish or individual oven-safe dishes.
Step 14: Sprinkle panko over pasta.
Step 15: Broil until top is golden, 2 - 3 minutes; serve immediately.
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